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Biotechnology Applications

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Biotechnology Applications
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Why would anyone grow plants like this?

Developing better crops is a significant aspect of biotechnology. Crops that are resistant to damage from insects or droughts must have a significant role in the world's future. And it all starts in the lab.

Applications of Biotechnology

Methods of biotechnology can be used for many practical purposes. They are used widely in both medicine and agriculture. To see how biotechnology can be used to solve crimes, watch the video "Justice DNA—Freeing the Innocent" at the following link: http://www.pubinfo.vcu.edu/secretsofthesequence/playlist_frame.asp .

Applications in Medicine

In addition to gene therapy for genetic disorders, biotechnology can be used to transform bacteria so they are able to make human proteins. Figure below shows how this is done to produce a cytokine , which is a small protein that helps fight infections. Proteins made by the bacteria are injected into people who cannot produce them because of mutations.

Genetically engineering bacteria to produce a human protein, a cytokine

Genetically Engineering Bacteria to Produce a Human Protein. Bacteria can be genetically engineered to produce a human protein, such as a cytokine. A cytokine is a small protein that helps fight infections.

Insulin was the first human protein to be produced in this way. Insulin helps cells take up glucose from the blood. People with type 1 diabetes have a mutation in the gene that normally codes for insulin. Without insulin, their blood glucose rises to harmfully high levels. At present, the only treatment for type 1 diabetes is the injection of insulin from outside sources. Until recently, there was no known way to make insulin outside the human body. The problem was solved by gene cloning. The human insulin gene was cloned and used to transform bacterial cells, which could then produce large quantities of human insulin.

Pharmacogenomics

We know that, thanks to our DNA, each of us is a little bit different. Some of those differences are obvious, like eye and hair color. Others are not so obvious, like how our bodies react to medication. Researchers are beginning to look at how to tailor medical treatments to our genetic profiles, in a relatively new field called pharmacogenomics . Some of the biggest breakthroughs have been in cancer treatment. For additional information on this “personalized medicine,” listen to http://www.kqed.org/quest/radio/personalized-medicine and see http://www.kqed.org/quest/blog/2009/09/11/reporters-notes-personalized-medicine/ .

Synthetic Biology

Imagine living cells acting as memory devices, biofuels brewing from yeast, or a light receptor taken from algae that makes photographs on a plate of bacteria. The new field of synthetic biology is making biology easier to engineer so that new functions can be derived from living systems. Find out the tools that synthetic biologists are using and the exciting things they are building at http://www.kqed.org/quest/television/decoding-synthetic-biology .

Applications in Agriculture

Biotechnology has been used to create transgenic crops. Transgenic crops are genetically modified with new genes that code for traits useful to humans. The diagram in Figure below shows how a transgenic crop is created. You can learn more about how scientists create transgenic crops with the interactive animation "Engineer a Crop: Transgenic Manipulation" at this link: http://www.pbs.org/wgbh/harvest/engineer/transgen.html .

Creating a transgenic crop

Creating a Transgenic Crop. A transgenic crop is genetically modified to be more useful to humans. The bacterium transfers the T-DNA (from the Ti plasmid) fragment with the desired gene into the host plant's nuclear genome.

Transgenic crops have been created with a variety of different traits, such as yielding more food, tasting better, surviving drought, and resisting insect pests. Scientists have even created a transgenic purple tomato that contains a cancer-fighting compound and others that have high levels of antioxidants (see Figure below ). See http://extension.oregonstate.edu/gardening/purple-tomato-debuts-‘indigo-rose’ for more information. To learn how scientists have used biotechnology to create plants that can grow in salty soil, watch the video "Salt of the Earth - Engineering Salt-tolerant Plants" at this link: http://www.sosq.vcu.edu/videos.aspx .

Transgenic purple tomato with cancer-fighting compound

Transgenic Purple Tomato. A purple tomato is genetically modified to contain a cancer-fighting compound. A gene for the compound was transferred into normal red tomatoes.

Biotechnology in agriculture is discussed at http://www.youtube.com/watch?v=IY3mfgbe-0c (6:40).

Summary

  • Biotechnology can be used to transform bacteria so they are able to make human proteins, such as insulin.
  • It can also be used to create transgenic crops, such as crops that yield more food or resist insect pests.

Practice I

Use these resources to answer the questions that follow.

  1. How can biotechnology help with agricultural issues?
  2. What is test-tube cloning?
  3. Describe Golden rice.
  4. Describe the applications of a Ti plasmid.
  1. Describe how advances in biotechnology have helped medical applications.
  1. What is a DNA fingerprint? Does every person have an unique DNA fingerprint?
  2. How is a DNA fingerprint used?

Practice II

Review

  1. What are transgenic crops?
  2. Make a flow chart outlining the steps involved in creating a transgenic crop.
  3. Explain how bacteria can be genetically engineered to produce a human protein.

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