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Phospholipid Bilayers

A membrane where phospholipid molecules orient to provide qualities necessary to maintain a cell in a water-based environment.

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Phospholipid Bilayers

All cells have a plasma membrane. This membrane surrounds the cell. So what is its role?

Can molecules enter and leave the cell? Yes. Can anything or everything enter or leave? No. So, what determines what can go in or out? Is it the nucleus? The DNA? Or the plasma membrane?

The Plasma Membrane

The plasma membrane (also known as the cell membrane ) forms a barrier between the cytoplasm inside the cell and the environment outside the cell. It protects and supports the cell and also controls everything that enters and leaves the cell. It allows only certain substances to pass through, while keeping others in or out. The ability to allow only certain molecules in or out of the cell is referred to as selective permeability or semipermeability . To understand how the plasma membrane controls what crosses into or out of the cell, you need to know its composition.

The plasma membrane is discussed at http://www.youtube.com/watch?v=-aSfoB8Cmic (6:16).

A Phospholipid Bilayer

The plasma membrane is composed mainly of phospholipids, which consist of fatty acids and alcohol. The phospholipids in the plasma membrane are arranged in two layers, called a phospholipid bilayer . As shown in Figure below , each phospholipid molecule has a head and two tails. The head “loves” water ( hydrophilic ) and the tails “hate” water ( hydrophobic ). The water-hating tails are on the interior of the membrane, whereas the water-loving heads point outwards, toward either the cytoplasm or the fluid that surrounds the cell.

Molecules that are hydrophobic can easily pass through the plasma membrane, if they are small enough, because they are water-hating like the interior of the membrane. Molecules that are hydrophilic, on the other hand, cannot pass through the plasma membrane—at least not without help—because they are water-loving like the exterior of the membrane.

Examines the phospholipid bilayer, the structure of the plasma membrane

Phospholipid Bilayer. The phospholipid bilayer consists of two layers of phospholipids, with a hydrophobic, or water-hating, interior and a hydrophilic, or water-loving, exterior. The hydrophilic (polar) head group and hydrophobic tails (fatty acid chains) are depicted in the single phospholipid molecule. The polar head group and fatty acid chains are attached by a 3-carbon glycerol unit.

See Insights into cell membranes via dish detergent at http://ed.ted.com/lessons/insights-into-cell-membranes-via-dish-detergent-ethan-perlstein for additional information on the cell membrane.


  • The plasma membrane forms a barrier between the cytoplasm and the environment outside the cell. The plasma membrane has selective permeability.
  • The plasma membrane is primarily composed of phospholipids arranged in a bilayer, with the hydrophobic tails on the interior of the membrane, and the hydrophilic heads pointing outwards.


Use these resources to answer the questions that follow.

  1. What are the two main components of the cell membrane?
  2. Describe the types of proteins that live in the cell membrane.
  3. Describe the orientation of the phospholipid molecule in the cell membrane.
  1. Are all cells surrounded by a membrane?
  2. Why are phospholipids considered an amphipathic molecule?
  3. What is a glycolipid?
  4. Describe the role of cholesterol in the cell membrane.
  1. What are the roles of the plasma membrane?
  2. What is the difference between hydrophilic and hydrophobic?
  3. What are the functions of proteins associated with the cell membrane?
  4. Why is the structure of the cell membrane described as "fluid mosaic"?


1. Describe the role of the plasma membrane.

2. Describe the composition of the plasma membrane.

3. Explain why hydrophobic (“water-hating”) molecules can easily cross the plasma membrane, while hydrophilic (“water-loving”) molecules cannot.


cell membrane

cell membrane

Thin coat of lipids (phospholipids) that surrounds and encloses a cell; barrier between the cytoplasm and the environment outside the cell; also known as the plasma membrane.
phospholipid bilayer

phospholipid bilayer

Double layer of phospholipid molecules that makes up a plasma membrane
plasma membrane

plasma membrane

Thin coat of lipids (phospholipids) that surrounds and encloses a cell; barrier between the cytoplasm and the environment outside the cell; also known as the cell membrane.


The ability to allow only certain molecules to cross the plasma membrane; selective permeability.

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