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2.16: Sodium-Potassium Pump

Difficulty Level: At Grade Created by: CK-12
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What is this incredible object?

Would it surprise you to learn that it is a human cell? The image represents an active human nerve cell. How nerve cells function will be the focus of another concept. However, active transport processes play a significant role in the function of these cells. Specifically, it is the sodium-potassium pump that is active in the axons of these nerve cells.

The Sodium-Potassium Pump

Active transport is the energy-requiring process of pumping molecules and ions across membranes "uphill" - against a concentration gradient. To move these molecules against their concentration gradient, a carrier protein is needed. Carrier proteins can work with a concentration gradient (during passive transport), but some carrier proteins can move solutes against the concentration gradient (from low concentration to high concentration), with an input of energy. As in other types of cellular activities, ATP supplies the energy for most active transport. One way ATP powers active transport is by transferring a phosphate group directly to a carrier protein. This may cause the carrier protein to change its shape, which moves the molecule or ion to the other side of the membrane. An example of this type of active transport system, as shown in Figure below, is the sodium-potassium pump, which exchanges sodium ions for potassium ions across the plasma membrane of animal cells.

The sodium-potassium pump system moves sodium and potassium ions against large concentration gradients. It moves two potassium ions into the cell where potassium levels are high, and pumps three sodium ions out of the cell and into the extracellular fluid.

As is shown in Figure above, three sodium ions bind with the protein pump inside the cell. The carrier protein then gets energy from ATP and changes shape. In doing so, it pumps the three sodium ions out of the cell. At that point, two potassium ions move in from outside the cell and bind to the protein pump. The sodium-potassium pump is found in the plasma membrane of almost every human cell and is common to all cellular life. It helps maintain cell potential and regulates cellular volume.

A more detailed look at the sodium-potassium pump is available at http://www.youtube.com/user/khanacademy#p/c/7A9646BC5110CF64/40/C_H-ONQFjpQ (13:53) and http://www.youtube.com/user/khanacademy#p/c/7A9646BC5110CF64/41/ye3rTjLCvAU (6:48).

The Electrochemical Gradient

The active transport of ions across the membrane causes an electrical gradient to build up across the plasma membrane. The number of positively charged ions outside the cell is greater than the number of positively charged ions in the cytosol. This results in a relatively negative charge on the inside of the membrane, and a positive charge on the outside. This difference in charges causes a voltage across the membrane. Voltage is electrical potential energy that is caused by a separation of opposite charges, in this case across the membrane. The voltage across a membrane is called membrane potential. Membrane potential is very important for the conduction of electrical impulses along nerve cells.

Because the inside of the cell is negative compared to outside the cell, the membrane potential favors the movement of positively charged ions (cations) into the cell, and the movement of negative ions (anions) out of the cell. So, there are two forces that drive the diffusion of ions across the plasma membrane—a chemical force (the ions' concentration gradient), and an electrical force (the effect of the membrane potential on the ions’ movement). These two forces working together are called an electrochemical gradient, and will be discussed in detail in "Nerve Cell" and "Nerve Impulses" concepts.


  • Active transport is the energy-requiring process of pumping molecules and ions across membranes against a concentration gradient.
  • The sodium-potassium pump is an active transport pump that exchanges sodium ions for potassium ions.


Use this resource to answer the questions that follow.

  1. Why is the size difference between a sodium and potassium ion important?
  2. Are there more sodium ions on the outside of cells or the inside?
  3. Are there more potassium ions on the outside of cells or the inside?
  4. Describe the role of ATP in active transport.


1. What is active transport?

2. Describe how the sodium-potassium pump functions.


active transport

active transport

Energy requiring movement of substances across a plasma membrane.
electrochemical gradient

electrochemical gradient

Difference across a membrane due to both a chemical force and an electrical force; drives the movement of ions across the membrane.
membrane potential

membrane potential

The electrical voltage difference across a cell membrane.
sodium-potassium pump

sodium-potassium pump

Active transport protein; exchanges sodium ions for potassium ions across the plasma membrane of animal cells.

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Difficulty Level:
At Grade
Date Created:
Feb 24, 2012
Last Modified:
May 17, 2016
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