Flexi Says: Both prokaryotic and eukaryotic cells have chromosomes, though eukaryotic chromosomes are typically more numerous and complex. Most prokaryotes have one circular chromosome. Additional, smaller segments of DNA are contained in circular plasmids. In eukaryotic cells, chromosomes are coiled structures made of DNA and proteins. Chromosomes are the form of the genetic material of a cell during cell division. It is this coiled structure that ensures proper segregation of the chromosomes during cell division. During other phases of the cell cycle, DNA is not coiled into chromosomes. Instead, it exists as a grainy material called chromatin.