Flexi Says: Some half-breeds are well known, like the mule which is a horse and donkey mix. But since hybrids are usually infertile, most are rare. Like Wolfdog – Wolf / Dog hybrid, Liger – Lion / Tiger hybrid, Zonkey – Zebra / Donkey hybrid, Zorse – Zebra / Horse hybrid, Leopon – Leopard / Lion hybrid, Beefalo – American Bison (Buffalo) / Domestic Cow hybrid, Wholphin – Bottlenose Dolphin / False Killer Whale hybrid and Sheep / Goat hybrid. Similarly, there are thousands of hybridized plants to choose from that feature traits like disease resistance, larger fruits, more yield, ornamental and prolific growth habits.