Flexi Says: Marfan syndrome is a genetic disorder caused by mutations that leads to defective protein in connective tissue. Its symptoms include heart and bone defects and unusually long, slender limbs and fingers. The mode of inheritance is autosomal dominance. Sickle cell anemia is also a genetic disorder caused by the effect of a mutation in which abnormal hemoglobin protein is present in red blood cells. In this, sickle-shaped red blood cells clog the tiny blood vessels, causing pain and damaging organs and joints. The mode of inheritance is autosomal recessive.