Flexi Says: Insulin, which lowers blood sugar, and glucagon, which raises it, are the important hormones involved in blood sugar regulation. When levels of blood sugar rise, whether as a result of glycogen conversion or from the digestion of a meal, insulin hormone is released from the pancreas. Insulin functions as a key to the door for the transportation of glucose. As soon as the glucose enters the cell, it is phosphorylated into Glucose-6-Phosphate in order to preserve the concentration gradient so glucose will continue to enter the cell. Insulin also provides signals to several other body systems and is the chief regulator of metabolic control in humans.