• Immunodeficiency occurs when the immune system is not working properly.
  • As a result, it cannot fight off pathogens that a normal immune system would be able to resist.
  • Most commonly, it occurs when T or B cells (or both) do not work as well as they should, or when your body doesn't produce enough antibodies.
  • Rarely, the problem is caused by a defective gene.
  • Inherited immunodef deficiency disorders that affect B cells include hypogammaglobulinemia, which usually leads to respiratory and gastrointestinal infections.
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