Flexi Says: Steroid hormones are made of lipids, such as phospholipids and cholesterol. They are fat-soluble, so they can diffuse across the plasma membrane of target cells and bind with receptors in the cytoplasm of the cell. The steroid hormone and receptor form a complex that moves into the nucleus and influences the expression of genes, essentially acting as a transcription factor. Examples of steroid hormones include cortisol and sex hormones.