Flexi Says: A monohybrid cross is a cross between two organisms with different variations at one genetic chromosome of interest. The character being studied in a monohybrid cross is governed by two alleles for a single gene. Mendel's first experiments were monohybrid crosses because he investigated just one characteristic of a pea plant at a time, e.g., flower color. In a dihybrid cross, the inheritance of two characteristics is tracked at the same time. The offspring of such a cross are called dihybrids. In his second set of experiments, Mendel investigated two characteristics at a time. For example, he crossed plants with yellow round seeds and plants with green wrinkled seeds.