Flexi Says: Hybridization is technically possible in related species only. Like a “humanzee” is possible due to the relative similarity between the genetic material of humans and chimpanzees. The genetic material of humans and dogs is far too dissimilar for hybridization to even be theoretically possible. Humans have 46 chromosomes (23 Pairs) and dogs have 78 (39 Pairs). If these sets of chromosomes try to cross over and create new DNA, after the 23 match up from the dog and human, the dog has an extra 16 pairs. It just fails to pair.