Flexi Says: Most of eukaryotic cells have a nucleus. Without a nucleus, cells lose the capacity for cell division, and they will be short-lived with very specific functions. For example, Mature red blood cells do not have a nucleus or other organelles. Lacking these components allows the cells to have more hemoglobin and carry more oxygen. Binucleated cells (cells with two nuclei) are sometimes observed in cancer. Liver cells, skeletal muscle fibers, and osteoclasts are normal cells having more than one nucleus.